Cold ischemia time and its impact in kidney transplant patients with a cadaveric donor at the Hospital de Clínicas
DOI:
https://doi.org/10.70108/nefrologiapy.2024.2.1.16Keywords:
cold ischemia, kidney transplant, cadaveric donorsAbstract
Introduction: Cold ischemia time (CIT) is a cause that affects the subsequent functionality of the organ.
General Objective: Determine the impact of CIT on kidney graft function from cadaveric donors. Specific objectives: Describe the variable‘s age and sex, previous clinical characteristics, type of induction used, and requirement for immediate post-transplant hemodialysis; relate the CIT with the renal profile at discharge and the days of hospitalization.
Patients and methods: Observational, partially prospective, cross-sectional, and analytical study, in kidney transplant recipients with a cadaveric donor from the Nephrology Adult Department of the Hospital de Clínicas FCM-UNA from January 2019 to August 2023.
Results: Of 43 patients, 67.4% were under 50 years of age, 62.7% were male, 58.1% had an unknown etiology and 97% were hemodialyzed, 60.4% received a previous transfusion, 27 patients received Basiliximab, and the rest received Antithymocyte globulin (rabbit) the average CIT has been 6.6 hours. 23 patients had a normal renal profile at discharge, with a CIT of up to 6 hours in 78.2%. Only 1 patient required immediate post-transplant hemodialysis and the hospitalization time in 79% of the patients was more than 8 days.
Conclusion: The impact of CIT on the renal profile at discharge and hospitalization time was not statistically significant for a mean of 6.6 hours.
Downloads
Metrics
References
(1) Salahudeen, Abdulla K., NaeemHaider, and Warren May. "Cold ischemia and the reduced long-term survival of cadaveric renal allografts." Kidneyinternational 65.2 (2004): 713-718.
(2) Rabbat CG, Thorpe KE, Russell JD, et al. Comparison of mortality risk for dialysis patients and cadaveric first renal transplant recipients in Ontario Canada. J Am SocNephrol. 2000;11:917–922.
(3) Held PJ, McCormick F, Ojo A, et al. A cost-benefit analysis of government compensation of kidney donors. Am J Transplant. 2016;16:877–885.
(4) Snyder RA, Moore DR, Moore DE. More donors or more delayed graft function? A cost-effectiveness analysis of DCD kidney transplantation. Clin Transplant. 2013;27:289–296.
(5) Schnitzler MA, Johnston K, Axelrod D, et al. Associations of renal function at 1 year after kidney transplantation with subsequent return to dialysis, mortality and healthcare costs. Transplantation. 2011;91:1347–1356.
(6) Englesbe MJ, Dimick JB, Fan Z, et al. Case mix, quality, and high-cost kidney transplant patients. Am J Transplant. 2009;9:1108–1114.
(7) Doucet B.P., Cho Y., Campbell S.B., et al. Resultados del trasplante de riñón en receptores ancianos: un estudio del Registro de Diálisis y Trasplante (ANZDATA) de Australia y Nueva Zelanda. Transplant Proc. 2021;53:1915– 1926
(8) Momper JD, Misel ML, McKayDB.Diferencias de sexo en el trasplante. Trasplante Rev (Orlando).2017;31:145-50.
(9) Karas M, Bernal I, Diaz O, Alshammari O, Baggett D, Bronk T, Chawdhury S, Eylon A, Garcia E, Haughton K, Kothe B, Joseph AM, Jacobs RJ. A Scoping Review of the Impact of COVID-19 on Kidney Transplant Patients in the United States. Cureus. 2023 Mar 3;15(3):e35725. doi: 10.7759/cureus.35725. PMID: 37025740; PMCID: PMC10072165.
(10) Bisigniano, L., et al. "Factors associated with patient and graft survival using kidneys from cadaveric donors in transplanted patients over 18 years of age in Argentina." Transplantation proceedings. Vol. 44. No. 7. Elsevier, 2012.
(11) Kayler LK, Lubetzky M, Yu X, Friedmann P. Influencia del tiempo de isquemia fría en los trasplantes de riñón de pequeños donantes pediátricos. Trasplante Directo. 2017 Jun 27;3(7):e184. doi: 10.1097/TXD.0000000000000668. PMID: 28706987; PMCID: PMC5498025.
(12) Gutierrez, Jorge Cubillos, et al. "Evaluación clínica y paraclínica de los pacientes con trasplante renal en 3 años de seguimiento de la Unidad de Trasplante Renal del Hospital Universitario de Neiva." Urología Colombiana 26.3 (2017): 169-179.
(13) Gómez González, Kimberly Adline. "La Insuficiencia renal crónica: paciente sometido a hemodiálisis." (2018).
(14) Pajewski, Russell, Patrick Gipson, and Michael Heung. "Predictors of post‐hospitalization recovery of renal function among patients with acute kidney injury requiring dialysis." Hemodialysis International 22.1 (2018): 66-73
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Juan Manuel López González, Lilian Beatriz Gomez Molinas, Marcelo Barrios Gini, Lourdes Carolina Vázquez Jiménez, Fernando Héctor Da Ponte
This work is licensed under a Creative Commons Attribution 4.0 International License.
